2. EARLY PHASE OF THE CHARACTERIZATION OF NEUROSERPIN 2.1. Isolation and initial characterization of neuroserpin Neuroserpin was isolated in a screen for neuronal proteins involved in axonal growth and synapse formation

1. Abstract 2. Early phase of the characterization of neuroserpin 2.1. Isolation and initial characterization of neuroserpin 2.2. The neuroserpin gene 2.3. The neuroserpin mRNA 2.4. Structural aspects of neuroserpin 3. Expression of neuroserpin 3.1. Regulation of neuroserpin expression 3.2. Expression of neuroserpin during development 3.3. Expression of neuroserpin in the adult 3.4. Investigation of neuroserpin expression using DNA microarray analysis 4. Physiological function of neuroserpin 4.1. In vitro complex formation 4.2. Neuroserpin function in the neuroendocrine tissue 4.3. Role of neuroserpin in the regulation of the emotional state 4.4. Role in synaptic plasticity 4.5. Neuroserpin catabolism 5. Pathological functions of neuroserpin 5.1. Neuroprotective role of neuroserpin in stroke 5.2. Neuroprotective role of neuroserpin in seizures 5.3. Is neuroserpin a cancer-associated gene? 5.4. Familial encephalopathy with neuroserpin inclusion bodies 5.4.1. Inclusion body distribution 5.4.2. Characterization of the accumulated neuroserpin 5.4.3. Mechanism of polymerization 5.4.4. Comparison of the four variants 5.4.5. Is the absence of neuroserpin or its accumulation responsible for the neurodegeneration? 6. References